Conjugation: Unconjugated.
Description: The Human ACE2 (Angiotensin-converting Enzyme 2) Recombinant Protein (OPSN00008) (amino acids 19-615) is expressed in Sf9 Baculovirus cells and purified using an Fc tag with Protein A/G chromatography followed by cleavage of the Fc tag. Useful for antibody or Coronavirus Spike interaction assays in a variety of formats.
Description of Target: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
Molecular Weight: 75kDa.
Product Format: Liquid. 50 mM Tris-HCL, 1M NaCl, pH 7.5.
Protein Name: angiotensin-converting enzyme 2.
Protein Size: AA 19-615.
Purification: Protein G followed by cleavage of Fc.
Purity: 0,9.
Tag: None
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