Background: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Description: Recombinant Human ACVR1C Protein with C-terminal human Fc tag
Molecular Weight: The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR1C-hFc is approximately 35-70 kDa due to glycosylation.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Human Fc Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: ACVR1C
Uniprot ID: Q8NER5
Usage: Research use only
Molecular Characterization: ACVR1C(Leu22-Glu113) hFc(Glu99-Ala330)
Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
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