Human DRD4-Strep full length protein-synthetic nanodisc

Human DRD4-Strep full length protein-synthetic nanodisc
SKU
DMAFLP120232-50
Packaging Unit
50 µg
Manufacturer
DIMA Biotechnology

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Background: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

Description: Human DRD4-Strep full length protein-synthetic nanodisc

Molecular Weight: The human full length DRD4-Strep protein has a MW of 43.9 kDa

Protein Families: GPCR,Transmembrane,Druggable Genome,

Protein Pathways: GPCRDB Class A Rhodopsin-like,GPCRDB Other,Monoamine GPCRs,

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Tag: C-Flag&Strep Tag

Expression Host: HEK293

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.

Target: DRD4

Uniprot ID: P21917

Usage: Research use only
More Information
SKU DMAFLP120232-50
Manufacturer DIMA Biotechnology
Manufacturer SKU FLP120232-50
Package Unit 50 µg
Quantity Unit STK
Conjugate Unconjugated
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