Background: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Description: Human S1PR1-Strep full length protein-synthetic nanodisc
Molecular Weight: The human full length S1PR1-Strep protein has a MW of 42.8 kDa
Protein Families: GPCR,Transmembrane,Druggable Genome,
Protein Pathways: GPCRDB Other,S1P Signaling,Small ligand GPCRs,Angiogenesis,Angiogenesis,G-Protein Coupled Receptors Signaling Pathway,
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Flag&Strep Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Target: S1PR1
Uniprot ID: P21453
Usage: Research use only
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