IACS-13909, CAS 2160546-07-4

Product Description: IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers[1].

Applications: Cancer-Kinase/protease

Formula: C17H18Cl2N6

References: [1]Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853.

CAS Number: 2160546-07-4

Molecular Weight: 377.27

Compound Purity: 99.97

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic)

Target: Phosphatase;SHP2

• SKU: MEXHY-137092-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-137092-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK