IAXO-102, CAS 1115270-63-7

Product Description: IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1].

Applications: COVID-19-immunoregulation

Formula: C35H71NO5

References: [1]Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.

CAS Number: 1115270-63-7

Molecular Weight: 585.94

Compound Purity: 98.0

Research Area: Inflammation/Immunology

Solubility: DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)/Ethanol : 50 mg/mL (ultrasonic)

Target: Toll-like Receptor (TLR)

• SKU: MEXHY-125171-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125171-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK