IBMX, CAS 28822-58-4

Shelf life (days): 730.0

Formulation: A crystalline solid

Formal Name: 3,9-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Purity: ≥98%

Formula Markup: C10H14N4O2

Formula Weight: 222.3

CAS Number: 28822-58-4

Notes: IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.{17520} By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists.{17521}

• SKU: CAY13347-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13347-500
• Package Unit: 500 mg
• Quantity Unit: STK