Product Description: ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).
Applications: COVID-19-immunoregulation
Formula: C23H19N3O3S2
References: [1]McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.
CAS Number: 313254-51-2
Molecular Weight: 449.55
Compound Purity: 98.65
Research Area: Cardiovascular Disease
Solubility: DMSO : ≥ 44 mg/mL
Target: Sodium Channel
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