Iclepertin, CAS 1421936-85-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: [5-(methylsulfonyl)-2-[(1R)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1R,5R)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]-methanone

Purity: ≥98%

Formula Markup: C20H18F6N2O5S

Formula Weight: 512.423819

CAS Number: 1421936-85-7

Notes: A GlyT1 inhibitor (IC50s = 5 and 5.2 nM for the human and rat transporter, respectively); selective for GlyT1 over GlyT2 (IC50 = >10 µM for the human transporter); increases CSF levels of glycine in rats when administered at doses of 0.2, 0.6, or 2 mg/kg; improves learning and memory in the social recognition test in rats at 0.2, 0.6, or 1.8 mg/kg; reverses MK-801-induced working memory deficits in the T-maze test in mice at 0.5, 1.5, or 4.5 mg/kg

• SKU: CAY41729-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41729-10
• Package Unit: 10 mg
• Quantity Unit: STK