Target Synonym: IDO1;IDO;IDO-1;INDO;indoleamine 2
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human IDO1
Dilution: WB 1:500-1:2000
Calculated MW: 45kDa
Observed MW: 40KDa
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