Shelf life (days): 365.0
Formulation: Lyophilized from sterile 50 mM Tris, pH 8.0, 500 mM sodium chloride, 0.5 mM PMSF, and 5 mM reduced glutathione
Uniprot ID: Q9Y6M1
Purity: ≥76% as estimated by SDS-PAGE
Formula Weight: 0.0
Notes: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is an RNA-binding protein (RBP) and a member of the zipcode-binding protein (ZBP) family.{49879} It is composed of two N-terminal RNA recognition motifs (RRMs) and four C-terminal heterogeneous nuclear ribonucleoprotein (hnRNP) K-homology (KH) domains. IGF2BP2 is ubiquitously expressed during development and localizes to the cytoplasm.{49879,49880} It exists as three isoforms: p58, which lacks an RRM motif, p62, which has a shortened linker region between KH2 and KH3, and the full-length isoform, p66.{49881} IGF2BP2 is involved in RNA processing through N6-methyladenosine (m6A) recognition, metabolism, neurogenesis, and embryonic development and interacts with several target transcripts, including IGF2, LAMB2, TRIM54, EIF4A1, and NTN4, as well as some mitochondrial genes.{49879,49882,49883} IGF2BP2 promotes or inhibits invasion and migration of cancer cells in vitro in a context-dependent manner.{49882,49883} SNPs in IGF2BP2 are associated with an increased risk of type 2 diabetes.{49884} Cayman’s IGF2BP2 long isoform (human, recombinant) protein consists of 836 amino acids and has a calculated molecular weight of 94 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular weight of the protein is 90 kDa.
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