Target Synonym: IL1F;IL-1F;pro IL1F;IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B;catabolin;IL-1B;pro Catabolin;pro IL1B;pro IL1F2;pro leukocytic endogenous mediator;pro leukocytic pyrogen;pro lymphocyte activating factor;pro mononuclear cell factor;IL-1F2;IL 1B;IL-1 beta
Background: Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Immunogen: A synthetic peptide corresponding to the center region of the Human IL-1 beta
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 31 kDa
Observed MW: 18 kDa, 34 kDa, 36 kDa
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