IL-17RA, Human (Biotinylated, HEK293, Fc-Avi)

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Product Description: IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F[1][2]. IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi), a Biotinylated  IL-17RA protein, is produced in  HEK293 cells with a C-Terminal Fc-tag and a C-Terminal Avi-tag.

Formula: 23765(Gene_ID)Q96F46-1(L33-W320)(Accession)

References: [1]Stéphane Nesmond, et al. Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid. Front Immunol. 2019 Sep 11;10:2107./[2]Xun Lin, et al. IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity. 2022 Feb 8;55(2):237-253.e8./[3]Laura Green, et al. Chronic Candidiasis in Children. Curr Allergy Asthma Rep. 2017 May;17(5):31./[4]Jayasri Das Sarma, et al. Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2009 Apr 28;6:14./[5]Erika A Rickel, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008 Sep 15;181(6):4299-310.

Molecular Weight: 78-100 kDa

Compound Purity: 95.0

• SKU: MEXHY-P78147-100UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P78147-100UG
• Package Unit: 100 μg
• Quantity Unit: STK