Product Type: Agonist.
CAS No.: 99011-02-6.
MolecularFormula: C14H16N4.
Molecular Weight: 240,3.
Source: Synthetic.
Purity: >98% (HPLC); NMR: (Conforms).
Solubility: May be dissolved in DMSO (2 mg/ml, warm) .
Appearance: White powder.
PubChem CID: 57469.
Scientific Background: Imiquimod activates the toll-like receptor7 /8 to secrete cytokines (primarily interferon-α (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)). It also has been shown to act as an adoside A1 and A2A receptor antagonist. It is clinically useful in the treatment of superficial basal cell carcinoma.
References: 1. Kan Y., et al. (2012) J Virol. 86(19): 10338-10346.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.