Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1H-indol-3-ol, 3-(hydrogen sulfate), monopotassium salt
Purity: ≥98%
Formula Markup: C8H6NO4S / K
Formula Weight: 251.30188
CAS Number: 2642-37-7
Notes: Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan (Item No. 29600).{27740} It is formed via sulfation of indoxyl, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver.{58559,27740} Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay).{58560} It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells.{58561} Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells.{58562} It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.{58561}
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