INF 4E, CAS 88039-46-7

Shelf life (days): 1460.0

Formulation: A liquid

Formal Name: 2-chloro-ß-hydroxy-a-methylene-benzenepropanoic acid, ethyl ester

Purity: ≥98%

Formula Markup: C12H13ClO3

Formula Weight: 240.68252

CAS Number: 88039-46-7

Notes: An NLRP3 inflammasome inhibitor; inhibits NLRP3 inflammasome by 51.8% at 10 µM; inhibits caspase 1 (Ki = 10.6 µM); active against S. aureus, C. diphtheriae, K. pneumoniae, and E. coli, (MICs = 18, 18, 18, and 16 µg/ml, respectively) and the fungus C. albicans (MIC = 13 µg/ml); inhibits ATP-induced pyroptosis in PMA-differentiated and LPS-stimulated THP-1 cells at 10 µM; induces cytotoxicity in HK-2 cells (IC50 = 67 µM); inhibits Aß42-induced increases in IL-1ß, IL-18, TNF-a, and GSDMD in SH-SY5Y cells at 10 µM

• SKU: CAY42315-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42315-5
• Package Unit: 5 mg
• Quantity Unit: STK