Product Description: Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].
Applications: Cancer-Kinase/protease
Formula: C41H72O9
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References: [1]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4./[2]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9./[3]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26./[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18./[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.
CAS Number: 56092-81-0
Molecular Weight: 709.01
Compound Purity: 99.0
Research Area: Cancer; Infection
Solubility: DMSO : 100 mg/mL (ultrasonic)/Ethanol : 100 mg/mL (ultrasonic)
Target: Antibiotic;Apoptosis;Bacterial;Calcium Channel;PKC
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