IPBT-5CA, CAS 306935-41-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-(1-methylethyl)-1H-benzotriazole-5-carboxylic acid

Purity: ≥98%

Formula Markup: C10H11N3O2

Formula Weight: 205.2

CAS Number: 306935-41-1

Notes: The G protein-coupled receptors GPR109A and GPR109B are recognized to be receptors for hydroxy-carboxylic acid (HCA) metabolites, are abundant in adipocytes, and are relevant to atherosclerosis and dyslipidemia.{24565,24562} IPBT-5CA is a selective agonist of GPR109B (HCA3; EC50 = 400 nM).{24563} It displays no activity at GPR109A (HCA2).{24563} IBC-293 inhibits forskolin-stimulated cAMP release in Chinese hamster ovary cells stably expressing GPR109B (EC50 = 54 nM) but not in cells expressing GPR109A.{24564} This is accompanied by a rapid and transient increase in intracellular calcium and activation of ERK1/2 through a pertussis toxin-sensitive Gi signaling pathway.{24564}

• SKU: CAY15223-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15223-1
• Package Unit: 1 g
• Quantity Unit: STK