Product Description: Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR). [3H]Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors[1][2]. Iperoxo is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Applications: Neuroscience-Neuromodulation
Formula: C10H17IN2O2
References: [1]Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70./[2]Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19.
CAS Number: 247079-84-1
Molecular Weight: 324.16
Compound Purity: 99.31
Research Area: Neurological Disease
Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: mAChR
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