Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[2-[2-chloro-3-[2-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propyl-3H-indolium, monoiodide
Purity: ≥98%
Formula Markup: C36H44ClN2 / I
Formula Weight: 667.1
CAS Number: 207399-07-3
Notes: IR 780 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells.{59759} It displays excitation/emission maxima of 780/799 nm, respectively.{59760} IR 780 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein (bromosulfalein; Item No. 21058), and targeted to the mitochondria.{59759} It has an additive effect on the increase in reactive oxygen species (ROS) production induced by sonodynamic therapy (SDT) in 4T1 breast cancer cells when used at a concentration of 16 µM.{59761} IR 780 (0.2 mg/kg, i.v.) preferentially accumulates in tumor tissue in MCF-7, HeLa, and MG-63 mouse xenograft models and in a syngeneic mouse model of chemically induced lung tumors, and its fluorescence is detectable for up to 20 days. It also has an additive effect on the SDT-induced reduction in tumor growth in an 4T1 murine mammary carcinoma model. IR 780 has been incorporated into heparin-folic acid-IR 780 nanoparticles for use in photothermal therapy.{59762}
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