Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-methyl-3-isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide
Purity: ≥98%
Formula Markup: C12H13N3O2
Formula Weight: 231.3
CAS Number: 59-63-2
Notes: Isocarboxazid is an inhibitor of monoamine oxidase (MAO; IC50 = 4.8 μM for rat brain MAO).{38498} It induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM. In vivo, isocarboxazid potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine). It inhibits 90% of MAO activity in isolated rat hearts and reduces cardiomegaly induced by isoproterenol (Item No. 15592) in rats at a dose of 20 mg/kg.{38385} Oral administration of isocarboxazid (10 mg/kg) increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, homovanillic acid (HVA; Item No. 20877), and 5-hydroxy indole-3-acetic acid (5-HIAA; Item No. 22889) by 43, 32, and 28%, respectively, in mouse brain.{38386} Formulations containing isocarboxazid have been used for the treatment of minor depression.{38387}
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