IV-255

Product Description: IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide[1].

Applications: Cancer-programmed cell death

Formula: C19H19F2N3O2

References: [1]Yang C, et al. Next-generation bromodomain inhibitors of the SWI/SNF complex enhance DNA damage and cell death in glioblastoma. J Cell Mol Med. 2023 Sep;27(18):2770-2781.

Molecular Weight: 359.37

Compound Purity: 98.41

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain

• SKU: MEXHY-155888-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155888-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK