Product Description: Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active.
Applications: COVID-19-immunoregulation
Formula: C18H30O2
References: [1]Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42../[2]Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8./[3]Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684.
CAS Number: 28872-28-8
Molecular Weight: 278.43
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Apoptosis
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