Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-dibenzo[a,g]quinolizinium, monochloride
Purity: ≥98%
Formula Markup: C20H20NO4 / Cl
Formula Weight: 373.82984
CAS Number: 6681-15-8
Notes: Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities.{45262,45263,45264,45265} It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM).{45262,45263} Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal.{45264} It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg.{45265} Jatrorrhizine is also a metabolite of berberine (Item No. 10006427).{45266}
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