JH-FK-08

Product Description: JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models[1].

Formula: C45H73N3O13

References: [1]Dome PA, et al., Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. bioRxiv [Preprint]. 2024 Nov 8:2024.09.27.615491.

Molecular Weight: 864.07

Research Area: Infection; Inflammation/Immunology

Target: Fungal;Interleukin Related

• SKU: MEXHY-170616-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170616-0
• Package Unit: Get quote
• Quantity Unit: STK