Product Description: JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C14H24N4O4
References: [1]Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694./[2]Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
CAS Number: 1998725-11-3
Molecular Weight: 312.36
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/Ethanol : 133.33 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Glutaminase
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