JIB-04, CAS 199596-05-9

Product Description: JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

Applications: Cancer-programmed cell death

Formula: C17H13ClN4

References: [1]Wang L, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 2013. 4: p. 2035./[2]Banelli B, et al. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget. 2017 Apr 4.

CAS Number: 199596-05-9

Molecular Weight: 308.76492

Compound Purity: 98.29

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)/Ethanol : 2 mg/mL (ultrasonic)

Target: Apoptosis;Histone Demethylase

• SKU: MEXHY-13953-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13953-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK