JK184, CAS 315703-52-7

Product Description: JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.

Applications: Cancer-programmed cell death

Formula: C19H18N4OS

References: [1]Zhang N, et al. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb 14;7(6):2609-24./[2]Colavito SA, et al. Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway. Breast Cancer Res. 2014 Sep 25;16(5):444.

CAS Number: 315703-52-7

Molecular Weight: 350.44

Compound Purity: 99.93

Research Area: Cancer

Solubility: DMSO : ≥ 50 mg/mL

Target: Hedgehog

• SKU: MEXHY-13307-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13307-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK