JNJ-10198409, CAS 627518-40-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine

Purity: ≥98%

Formula Markup: C18H16FN3O2

Formula Weight: 325.3

CAS Number: 627518-40-5

Notes: Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity.{14399} JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value of 4.2 nM when tested in human coronary artery smooth muscle cells.{13764} JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis.

• SKU: CAY10008131-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10008131-5
• Package Unit: 5 mg
• Quantity Unit: STK