Product Description: JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].
Applications: COVID-19-immunoregulation
Formula: C40H35N2O6P
References: [1]Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280(18):18001-7.
CAS Number: 518062-14-1
Molecular Weight: 670.69
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Cathepsin