Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(4-fluoro-3-methylphenyl)-3-[[[(3S)-tetrahydro-3-furanyl]amino]sulfonyl]-benzamide
Purity: ≥98%
Formula Markup: C18H19FN2O4S
Formula Weight: 378.418943
CAS Number: 1572510-42-9
Notes: JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly.{42633,42634} It reduces viral DNA load in HBV-infected HepG2.2.15 cells (EC50 = 121 nM) without affecting cell growth.{42634} It also reduces viral DNA load in primary human hepatocytes infected with the HBV genotypes Ae, Bj, C, and D (EC50s = 101, 240, 119, and 200 nM, respectively). JNJ-632 prevents formation of covalently closed circular DNA in HBV-infected primary human hepatocytes in a concentration-dependent manner when administered in combination with the HBV viral inoculum. In vivo, JNJ-632 (200 mg/kg per day) reduces plasma HBV DNA content in HBV-infected humanized mice.{42633}
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