Product Description: JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB)[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C17H17ClN2O2
References: [1]Dvorak CA, et al. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8./[2]Liu C, et al. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25.
CAS Number: 1802326-66-4
Molecular Weight: 316.78
Compound Purity: 99.90
Research Area: Neurological Disease
Solubility: DMSO : ≥ 50 mg/mL
Target: GPR139
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