K-975, CAS 2563855-03-6

Product Description: K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

Applications: Cancer-programmed cell death

Formula: C16H14ClNO2

References: [1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415.

CAS Number: 2563855-03-6

Molecular Weight: 287.74

Compound Purity: 99.64

Research Area: Cancer

Solubility: DMSO : 220 mg/mL (ultrasonic)

Target: YAP

• SKU: MEXHY-138565-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138565-25
• Package Unit: 25 mg
• Quantity Unit: STK