K882

Shelf life (days): 1460

Info: An inhibitor of Src kinase; binds to Src (Kd = 315 nM), decreases phosphorylation at the Y416 activation site, and increases phosphorylation at the Y527 inactivation site; reduces the proliferation of wild-type NCI H358 cells and KRASG12C-expressing NCI H358 cells (IC50s = 2.14 and 2.03 µM, respectively); inhibits migration and invasion of NCI H358 cells at 2, 4, and 8 µM, induces cell cycle arrest in the G2/M phase at 1, 4, and 8 µM, and induces apoptosis at 4 and 8 µM; reduces tumor volume in an NCI H358 mouse xenograft model at 25, 50, and 100 mg/kg

Formulation: A crystalline solid

Formal Name: (E)-4-(2,5-dimethoxystyryl)quinazoline

Purity: ≥95%

Formula Markup: C18H16N2O2

Formula Weight: 292.338

• SKU: CAY43422-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43422-10
• Package Unit: 10 mg
• Quantity Unit: STK