KHK-IN-1 (hydrochloride), CAS 1303470-48-5

Product Description: KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity[1].

Formula: C21H27ClN8S

References: [1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.

CAS Number: 1303470-48-5

Molecular Weight: 459.01

Compound Purity: 98.47

Research Area: Metabolic Disease

Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Ketohexokinase

• SKU: MEXHY-12841A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12841A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK