KIRA6, CAS 1589527-65-0

Product Description: KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC50 of 0.6 µM[2]. KIRA6 can trigger an apoptotic response[1].

Applications: Cancer-Kinase/protease

Formula: C28H25F3N6O

References: [1]Mahameed M,et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019 Apr 1;10(4):300./[2]Ghosh R, et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158(3):534-48.

CAS Number: 1589527-65-0

Molecular Weight: 518.53

Compound Purity: 99.86

Research Area: Cancer; Metabolic Disease; Inflammation/Immunology

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: IRE1

• SKU: MEXHY-19708-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19708-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK