Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monohydrochloride
Purity: ≥98%
Formula Markup: C26H29ClN2O4S / HCl
Formula Weight: 537.5
CAS Number: 1956426-56-4
Notes: KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).{17325} It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase.{17325} It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).{17326} More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.{17327,17328,17329}
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