Product Description: Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells[1]. Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities[3], protects against the development of arthritis in Rheumatoid arthritis (RA) animal models[2].
Applications: Cancer-programmed cell death
Formula: C20H22N2O
References: [1]Zhang X, et al. Apoptotic Effect of Koumine on Human Breast Cancer Cells and the Mechanism Involved. Cell Biochem Biophys. 2015 Jun;72(2):411-6./[2]Yang J, et al. Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats. J Nat Prod. 2016 Oct 28;79(10):2635-2643./[3]Jin GL, et al. Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain. Neural Plast. 2018 Mar 25;2018:9347696.
CAS Number: 1358-76-5
Molecular Weight: 306.40
Compound Purity: 99.97
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Bcl-2 Family
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