KPT-185, CAS 1333151-73-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2Z-propenoic acid, 1-methylethyl ester

Purity: ≥98%

Formula Markup: C16H16F3N3O3

Formula Weight: 355.3

CAS Number: 1333151-73-7

Notes: KPT-185 is an inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity.{47263,31566} It reduces proliferation in a panel of patient-derived acute myeloid leukemia cells (IC50s = 100-500 nM).{47263} KPT-185 induces cell cycle arrest in the G1 phase and apoptosis in MOLT-4 T cell acute lymphoblastic leukemia cells and in a panel of six non-small cell lung cancer (NSCLC) cell lines in a time- and dose-dependent manner.{31566,47264}

• SKU: CAY26074-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26074-25
• Package Unit: 25 mg
• Quantity Unit: STK