KRAS inhibitor-9, CAS 300809-71-6

Product Description: KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].

Applications: Cancer-Kinase/protease

Formula: C13H9ClN2S2

References: [1]Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.

CAS Number: 300809-71-6

Molecular Weight: 292.81

Compound Purity: 99.85

Research Area: Cancer

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Apoptosis;Ras

• SKU: MEXHY-137497-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-137497-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK