KRIBB11, CAS 342639-96-7

Product Description: KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.

Applications: Cancer-programmed cell death

Formula: C13H12N6O2

References: [1]Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286(3):1737-47/[2]Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87(3):445-55

CAS Number: 342639-96-7

Molecular Weight: 284.27

Compound Purity: 99.54

Research Area: Cancer

Solubility: DMSO : 150 mg/mL (ultrasonic)

Target: Apoptosis;HSP

• SKU: MEXHY-100872-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100872-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK