KY-05009, CAS 1228280-29-2

Product Description: KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1].

Applications: Cancer-Kinase/protease

Formula: C18H16N4O2S

References: [1]Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101.

CAS Number: 1228280-29-2

Molecular Weight: 352.41

Compound Purity: 99.24

Research Area: Cancer

Solubility: DMSO : 83.33 mg/mL (ultrasonic)

Target: Apoptosis;MAP4K;Wnt

• SKU: MEXHY-124745-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124745-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK