Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
Purity: ≥98%
Formula Markup: C23H26O4
Formula Weight: 366.45014
CAS Number: 6508-43-6
Notes: An antagonist of NPY receptor Y5 (IC50s = 26 and 31 nM for the human and rat receptors, respectively); reduces bovine pancreatic peptide-induced, but not NPY-induced, food intake in satiated rats at 30 µg, i.c.v.; reduces body weight in DIO mice to a greater extent than pair-fed DIO mice without reducing food intake at 100 mg/kg; increases expression of the genes encoding UCP1 and UCP3 in BAT and the β3-adrenergic receptor in WAT of DIO mice compared to pair-fed and ad libitum-fed DIO mice; does not increase energy expenditure in DIO mice compared to lean mice