Product Description: L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C27H34N6O5
References: [1]Patane MA, et al. 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. J Med Chem. 1998 Apr 9;41(8):1205-8./[2]Tobias Böhmer, et al. The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014 Aug; 171(16): 3858–3867.
CAS Number: 189349-50-6
Molecular Weight: 522.60
Compound Purity: 99.95
Research Area: Cardiovascular Disease; Endocrinology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Adrenergic Receptor
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