L-779450, CAS 303727-31-3

Product Description: L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.

Applications: Cancer-Kinase/protease

Formula: C20H14ClN3O

References: [1]Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6./[2]Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17(9):1765-82./[3]Berger A, et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-440.

CAS Number: 303727-31-3

Molecular Weight: 347.80

Compound Purity: 98.75

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Autophagy;Raf

• SKU: MEXHY-12787-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12787-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK