L-α-Hydroxyglutaric Acid (sodium salt), CAS 63512-50-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2S-hydroxy-pentanedioic acid, disodium salt

Purity: ≥95%

Formula Markup: C5H8O5 / 2Na

Formula Weight: 194.1

CAS Number: 63512-50-5

Notes: L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}

• SKU: CAY11876-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11876-5
• Package Unit: 5 mg
• Quantity Unit: STK