Product Description: L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS)[1][2][3][4][5].
Applications: Neuroscience-Neuromodulation
Formula: C5H12N2O3S
References: [1]Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589. /[2]Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415. /[3]Pawlik MJ, et al. Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats[J]. Brain Res. 2021 Feb 15;1753:147253. /[4]Prakash, O., et al. Isolation and Characterization of Ammonia Secreting Cyanobacterium Nostoc sp. NDUPC007 from Agriculture Fields of Varanasi[J]. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 2022 January 10; 92, 89–93. /[5]Pawlik MJ, et al. Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose[J]. Int J Mol Sci. 2021 Oct 15;22(20):11127.
CAS Number: 15985-39-4
Molecular Weight: 180.23
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 50 mg/mL (ultrasonic)
Target: Glutaminase
English
Deutsch
