Laduviglusib (trihydrochloride) (Standard), CAS 1782235-14-6

Laduviglusib (trihydrochloride) (Standard), CAS 1782235-14-6
SKU
MEXHY-10182BR-0
Packaging Unit
Get quote
Manufacturer
MedChemExpress

Availability: loading...
Price is loading...
Product Description: Laduviglusib (trihydrochloride) (Standard) is the analytical standard of Laduviglusib (trihydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3].

Formula: C22H21Cl5N8

References: [1]Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95./[2]Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004./[3]Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273./[4]Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566./[5]Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892.

CAS Number: 1782235-14-6

Molecular Weight: 574.72

Research Area: Cancer

Target: Autophagy;GSK-3;Organoid;Reference Standards;Wnt;β-catenin
More Information
SKU MEXHY-10182BR-0
Manufacturer MedChemExpress
Manufacturer SKU HY-10182BR-0
Package Unit Get quote
Quantity Unit STK
Product information (PDF)
×
MSDS (PDF)
×