Shelf life (days): 730.0
Formulation: A solution in ethanol
Formal Name: (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone
Purity: ≥95%
Formula Markup: C22H31NO5S
Formula Weight: 421.6
CAS Number: 76343-93-6
Notes: Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM, 30 min).{{15842,15843,15838} Latrunculin A (1-10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes.{15841} Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis.{15839} Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability.{15840}
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