Lazertinib, CAS 1903008-80-9

Shelf life (days): 730.0

Formulation: A solid

Formal Name: N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-4-methoxy-2-(4-morpholinyl)phenyl]-2-propenamide

Purity: ≥98%

Formula Markup: C30H34N8O3

Formula Weight: 554.64308

CAS Number: 1903008-80-9

Notes: Lazertinib is an irreversible inhibitor of mutant EGFRs (IC50s = 1.7, 2, and 3.3 nM for EGFRL858R/T790M, EGFRDel19/T790M, and EGFRDel19, respectively).{52289} It is selective for mutant EGFRs over wild-type EGFR, HER2, and HER4 (IC50s = 76, 364, and 1,017 nM, respectively). Lazertinib reduces viability of Ba/F3 cells expressing mutant EGFRs (IC50s = 3.3-5.7 nM). In vivo, lazertinib (1, 3, and 10 mg/kg) reduces tumor volume in an EGFRT790M mutant H1975 non-small cell lung cancer (NSCLC) mouse xenograft model.

• SKU: CAY29670-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29670-25
• Package Unit: 25 mg
• Quantity Unit: STK